The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women (2023)

Kanis, J. A., Oden, A., Johnell, O., Johansson, H., De Laet, C., Brown, J., Burckhardt, P., Cooper, C., Christiansen, C., Cummings, S., Eisman, J. A., Fujiwara, S., Glüer, C., Goltzman, D., Hans, D., Krieg, M. A., La Croix, A., McCloskey, E., Mellstrom, D., ... Yoshimura, N. (2007). The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International, 18(8), 1033-1046. https://doi.org/10.1007/s00198-007-0343-y

Kanis, J. A. ; Oden, A. ; Johnell, O. et al. / The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. In: Osteoporosis International. 2007 ; Vol. 18, No. 8. pp. 1033-1046.

@article{2a2573b1732c4a069b3cbe33b8661807,

title = "The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women",

abstract = "Summary: BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. Introduction and hypotheses: To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD. Methods: Nine population-based studies were studied in which BMD and CRFs were documented at baseline. Poisson regression models were developed for hip fracture and other osteoporotic fractures, with and without hip BMD. Fracture risk was expressed as gradient of risk (GR, risk ratio/SD change in risk score). Results: CRFs alone predicted hip fracture with a GR of 2.1/SD at the age of 50 years and decreased with age. The use of BMD alone provided a higher GR (3.7/SD), and was improved further with the combined use of CRFs and BMD (4.2/SD). For other osteoporotic fractures, the GRs were lower than for hip fracture. The GR with CRFs alone was 1.4/SD at the age of 50 years, similar to that provided by BMD (GR=1.4/SD) and was not markedly increased by the combination (GR=1.4/SD). The performance characteristics of clinical risk factors with and without BMD were validated in eleven independent population-based cohorts. Conclusions: The models developed provide the basis for the integrated use of validated clinical risk factors in men and women to aid in fracture risk prediction. {\textcopyright} 2007 International Osteoporosis Foundation and National Osteoporosis Foundation.",

keywords = "Bone mineral density, Hip fracture, Meta-analysis, Osteoporotic fracture, Risk assessment",

author = "Kanis, {J. A.} and A. Oden and O. Johnell and H. Johansson and {De Laet}, C. and J. Brown and P. Burckhardt and C. Cooper and C. Christiansen and S. Cummings and Eisman, {J. A.} and S. Fujiwara and C. Gl{\"u}er and D. Goltzman and D. Hans and Krieg, {M. A.} and {La Croix}, A. and E. McCloskey and D. Mellstrom and Melton, {L. J.} and H. Pols and J. Reeve and K. Sanders and Schott, {A. M.} and A. Silman and D. Torgerson and {Van Staa}, T. and Watts, {N. B.} and N. Yoshimura",

year = "2007",

month = aug,

doi = "10.1007/s00198-007-0343-y",

language = "English",

volume = "18",

pages = "1033--1046",

journal = "Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA",

issn = "1433-2965",

publisher = "Springer Nature",

number = "8",

}

Kanis, JA, Oden, A, Johnell, O, Johansson, H, De Laet, C, Brown, J, Burckhardt, P, Cooper, C, Christiansen, C, Cummings, S, Eisman, JA, Fujiwara, S, Glüer, C, Goltzman, D, Hans, D, Krieg, MA, La Croix, A, McCloskey, E, Mellstrom, D, Melton, LJ, Pols, H, Reeve, J, Sanders, K, Schott, AM, Silman, A, Torgerson, D, Van Staa, T, Watts, NB & Yoshimura, N 2007, 'The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women', Osteoporosis International, vol. 18, no. 8, pp. 1033-1046. https://doi.org/10.1007/s00198-007-0343-y

The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. / Kanis, J. A.; Oden, A.; Johnell, O. et al.

In: Osteoporosis International, Vol. 18, No. 8, 08.2007, p. 1033-1046.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women

AU - Kanis, J. A.

AU - Oden, A.

AU - Johnell, O.

AU - Johansson, H.

AU - De Laet, C.

AU - Brown, J.

AU - Burckhardt, P.

AU - Cooper, C.

AU - Christiansen, C.

AU - Cummings, S.

AU - Eisman, J. A.

AU - Fujiwara, S.

AU - Glüer, C.

AU - Goltzman, D.

AU - Hans, D.

AU - Krieg, M. A.

AU - La Croix, A.

AU - McCloskey, E.

AU - Mellstrom, D.

AU - Melton, L. J.

AU - Pols, H.

AU - Reeve, J.

AU - Sanders, K.

AU - Schott, A. M.

AU - Silman, A.

AU - Torgerson, D.

AU - Van Staa, T.

AU - Watts, N. B.

AU - Yoshimura, N.

PY - 2007/8

Y1 - 2007/8

N2 - Summary: BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. Introduction and hypotheses: To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD. Methods: Nine population-based studies were studied in which BMD and CRFs were documented at baseline. Poisson regression models were developed for hip fracture and other osteoporotic fractures, with and without hip BMD. Fracture risk was expressed as gradient of risk (GR, risk ratio/SD change in risk score). Results: CRFs alone predicted hip fracture with a GR of 2.1/SD at the age of 50 years and decreased with age. The use of BMD alone provided a higher GR (3.7/SD), and was improved further with the combined use of CRFs and BMD (4.2/SD). For other osteoporotic fractures, the GRs were lower than for hip fracture. The GR with CRFs alone was 1.4/SD at the age of 50 years, similar to that provided by BMD (GR=1.4/SD) and was not markedly increased by the combination (GR=1.4/SD). The performance characteristics of clinical risk factors with and without BMD were validated in eleven independent population-based cohorts. Conclusions: The models developed provide the basis for the integrated use of validated clinical risk factors in men and women to aid in fracture risk prediction. © 2007 International Osteoporosis Foundation and National Osteoporosis Foundation.

AB - Summary: BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. Introduction and hypotheses: To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD. Methods: Nine population-based studies were studied in which BMD and CRFs were documented at baseline. Poisson regression models were developed for hip fracture and other osteoporotic fractures, with and without hip BMD. Fracture risk was expressed as gradient of risk (GR, risk ratio/SD change in risk score). Results: CRFs alone predicted hip fracture with a GR of 2.1/SD at the age of 50 years and decreased with age. The use of BMD alone provided a higher GR (3.7/SD), and was improved further with the combined use of CRFs and BMD (4.2/SD). For other osteoporotic fractures, the GRs were lower than for hip fracture. The GR with CRFs alone was 1.4/SD at the age of 50 years, similar to that provided by BMD (GR=1.4/SD) and was not markedly increased by the combination (GR=1.4/SD). The performance characteristics of clinical risk factors with and without BMD were validated in eleven independent population-based cohorts. Conclusions: The models developed provide the basis for the integrated use of validated clinical risk factors in men and women to aid in fracture risk prediction. © 2007 International Osteoporosis Foundation and National Osteoporosis Foundation.

KW - Bone mineral density

KW - Hip fracture

KW - Meta-analysis

KW - Osteoporotic fracture

KW - Risk assessment

U2 - 10.1007/s00198-007-0343-y

DO - 10.1007/s00198-007-0343-y

M3 - Article

C2 - 17323110

VL - 18

SP - 1033

EP - 1046

JO - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

SN - 1433-2965

IS - 8

ER -

Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International. 2007 Aug;18(8):1033-1046. doi: 10.1007/s00198-007-0343-y